Research Interests

• bacterial molecular genetics
• human gut microbiome
• technology development

Publications and Preprints

P. Spanogiannopoulos, T.S. Kyaw, B.G.H. Guthrie, P.H. Bradley, J.V. Lee, J. Melamed, Y.N.A. Malig, K.N. Lam, D. Gempis, M. Sandy, W. Kidder, E.L. Van Blarigan, C.E. Atreya, A. Venook, R.R. Gerona, A. Goga, K.S. Pollard, P.J. Turnbaugh (2022). Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism. [Nature Microbiology] [bioRxiv] [Pubmed]

K.N. Lam, P. Spanogiannopoulos, P. Soto-Perez, M. Alexander,  M.J. Nalley, J.E. Bisanz, R.R. Nayak, A.M. Weakley,  F.B. Yu, P.J. Turnabugh (2021). Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome. [Cell Reports] [bioRxiv] [Pubmed]

J.E. Bisanz, P. Soto-Perez, C. Noecker, A.A. Aksenov, K.N. Lam, G.E. Kenney, E.N. Bess, H.J. Haiser, T.S. Kyaw, F.B. Yu, V.M. Rekdal, C.W.Y. Ha, S. Devkota, E.P. Balskus, P.C. Dorrestein, E. Allen-Vercoe, P.J. Turnbaugh (2020). A genomic toolkit for the mechanistic dissection of intractable human gut bacteria. [Cell Host & Microbe] [Pubmed]

K.N. Lam, M. Alexander, P.J. Turnbaugh (2019). Precision medicine goes microscopic: engineering the microbiome to improve drug outcomes. [Cell Host & Microbe] [Pubmed]

P. Soto-Perez, J.E. Bisanz, J.D. Berry, K.N. Lam, J. Bondy-Denomy, P.J. Turnbaugh (2019). CRISPR-Cas system of a prevalent human gut bacterium reveals hyper-targeting against phages in a human virome catalog. [Cell Host & Microbe] [Pubmed]

K.N. Lam, E.C. Martens, T.C. Charles (2018). Developing a Bacteroides system for function-based screening of DNA from the human gut microbiome. [PDF] [mSystems] [Pubmed]

K.N. Lam, J. Cheng, K. Engel, J.D. Neufeld, T.C. Charles (2015). Current and future resources for functional metagenomics. [PDF] [Frontiers in Microbiology] [Pubmed]

K.N. Lam, T.C. Charles (2015). Strong spurious transcription likely contributes to DNA insert bias in typical metagenomic clone libraries. [PDF] [Microbiome] [bioRxiv] [Pubmed]

H.S. Najafabadi, S. Mnaimneh, F.W. Schmitges, M. Garton, K.N. Lam, A. Yang, M. Albu, M.T. Weirauch, E. Radovani, P.M. Kim, J. Greenblatt, B.J. Frey, T.R. Hughes (2015). C2H2 zinc fingers greatly expand the human regulatory lexicon. [Nature Biotechnology] [PubMed]

K.N. Lam, M.W. Hall, K. Engel, G. Vey, J. Cheng, J.D. Neufeld, T.C. Charles (2014). Evaluation of a pooled strategy for high-throughput sequencing of cosmid clones from metagenomic libraries. [PDF] [PLOS One] [PubMed]

K.N. Lam, H. van Bakel, A.G. Cote, A. van der Ven, T.R. Hughes (2011).  Sequence specificity is obtained from the majority of modular C2H2 zinc finger arrays. [PDF] [Nucleic Acids Research] [PubMed]

M.A. Trainer, D.S. Capstick, A. Zachertowska, K.N. Lam, S.R.D. Clark, T.C. Charles (2010). Identification and characterization of the intracellular poly-3-hydroxybutyrate depolymerase PhaZ of Sinorhizobium meliloti[PDF] [BMC Microbiology] [PubMed]