Research Interests

  • bacterial molecular genetics
  • functional metagenomics
  • human gut microbiome
  • bacteriophages
  • method development

Publications and Preprints

K.N. Lam, P. Spanogiannopoulos, P. Soto-Perez, M. Alexander,  M.J. Nalley, J.E. Bisanz, F.B. Yu, P.J. Turnabugh (2020). Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiota. [bioRxiv]

J.E. Bisanz, P. Soto-Perez, C. Noecker, A.A. Aksenov, K.N. Lam, G.E. Kenney, E.N. Bess, H.J. Haiser, T.S. Kyaw, F.B. Yu, V.M. Rekdal, C.W.Y. Ha, S. Devkota, E.P. Balskus, P.C. Dorrestein, E. Allen-Vercoe, P.J. Turnbaugh (2020). A genomic toolkit for the mechanistic dissection of intractable human gut bacteria. [Cell Host & Microbe] [Pubmed]

P. Spanogiannopoulos, P.H. Bradley, J. Melamed, Y.N.A. Malig, K.N. Lam, R.R. Gerona, K.S. Pollard, P.J. Turnbaugh (2019). Drug resistant gut bacteria mimic a host mechanism for anticancer drug clearance. [bioRxiv]

K.N. Lam*, M. Alexander*, P.J. Turnbaugh (2019). Precision medicine goes microscopic: engineering the microbiome to improve drug outcomes. [Cell Host & Microbe] [Pubmed]

P. Soto-Perez*, J.E. Bisanz*, J.D. Berry, K.N. Lam, J. Bondy-Denomy, P.J. Turnbaugh (2019). CRISPR-Cas system of a prevalent human gut bacterium reveals hyper-targeting against phages in a human virome catalog. [Cell Host & Microbe] [Pubmed]

K.N. Lam, E.C. Martens, T.C. Charles (2018). Developing a Bacteroides system for function-based screening of DNA from the human gut microbiome. [PDF] [mSystems] [Pubmed]

K.N. Lam, J. Cheng, K. Engel, J.D. Neufeld, T.C. Charles (2015). Current and future resources for functional metagenomics. [PDF] [Frontiers in Microbiology] [Pubmed]

K.N. Lam, T.C. Charles (2015). Strong spurious transcription likely contributes to DNA insert bias in typical metagenomic clone libraries. [PDF] [Microbiome] [bioRxiv] [Pubmed]

H.S. Najafabadi, S. Mnaimneh, F.W. Schmitges, M. Garton, K.N. Lam, A. Yang, M. Albu, M.T. Weirauch, E. Radovani, P.M. Kim, J. Greenblatt, B.J. Frey, T.R. Hughes (2015). C2H2 zinc fingers greatly expand the human regulatory lexicon. [Nature Biotechnology] [PubMed]

K.N. Lam, M.W. Hall, K. Engel, G. Vey, J. Cheng, J.D. Neufeld, T.C. Charles (2014). Evaluation of a pooled strategy for high-throughput sequencing of cosmid clones from metagenomic libraries. [PDF] [PLOS One] [PubMed]

K.N. Lam, H. van Bakel, A.G. Cote, A. van der Ven, T.R. Hughes (2011).  Sequence specificity is obtained from the majority of modular C2H2 zinc finger arrays. [PDF] [Nucleic Acids Research] [PubMed]

M.A. Trainer, D.S. Capstick, A. Zachertowska, K.N. Lam, S.R.D. Clark, T.C. Charles (2010). Identification and characterization of the intracellular poly-3-hydroxybutyrate depolymerase PhaZ of Sinorhizobium meliloti[PDF] [BMC Microbiology] [PubMed]